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KMID : 0923620140140040201
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Immune Network
2014 Volume.14 No. 4 p.201 ~ p.206
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IL-33 Priming Enhances Peritoneal Macrophage Activity in Response to Candida albicans
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Tran Vuvi G.
Cho Hong-R.
Kwon Byung-Suk
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Abstract
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IL-33 is a member of the IL-1 cytokine family and plays a role in the host defense against bacteria, viruses, and fungi. In this study, we investigated the function of IL-33 and its re-ceptor in in vitro macrophage responses to Candida albicans. Our results demonstrate that pre-sensitization of isolated peritoneal macrophages with IL-33 enhanced their pro-inflammatory cytokine production and phagocytic activ-ity in response to C. albicans. These macrophage activities were entirely dependent on the ST2-MyD88 signaling pathway. In addition, pre-sensitization with IL-33 also in-creased ROS production and the subsequent killing ability of macrophages following C. albicans challenge. These results indicate that IL-33 may increase anti-fungal activity against Candida through macrophage-mediated resistance mechani-sms.
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KEYWORD
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Peritoneal macrophage, IL-33, Candida albicans, Pro-inflammatory cytokines, Phagocytosis, Fungicidal activity
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